I. Benedek jr²., Theodora Benedek², I. Kovács², Claudia Matei¹, Monica Chitu¹, Diana Horga¹, I. A. Sârbu-Pop², Sz. Madaras², Melinda Kurtinecz¹, Zsuzsanna Suciu², I. Benedek¹

¹ Emergency County Hospital Tg Mureș, Cardiology Clinic

² Medicine and  Pharmacy University Tg Mureș, Discipline of Internal Medicine 6

Purpose: Our  study aims to evaluate the  role of Computerized 3D  Echocardiography(C3DE) in the  complex, objective assesment of

LV remodelling in postinfarction phase, based on objective parameters.

Methods: Gr.  1–28 patients with AMI  treated with primary PCI.  A subgroup(1A-9 patients) of these patients benefited of intracoro- nary  stem cell  injection. Gr.  2–26 patients with late  interventional reopening of a chronic occluded coronary artery. In all patients we performed C3DE at the  time of randomisation (baseline) and  at 6 months follow-up, with complex analysis of segmental volumes and  kinetics and  the  following indexes were  calculated for assesment of LV remodelling. Index of segmentar dilatation (ISD); Remodelling index(RI)

Results: Ejection fraction(EF) increased from  42.5% to 45.2% in group 1 compared to an increase from  41.2% to 44.3% in Group 2. At 6 months follow-up we  recorded a regression of RI in gr.1  with 32.75% for infarcted segments, and  in gr.2 a regression of 17.25% in the  infarcted segments. In the  stem cell subgroup the  regression of RI was 34.5% for infarcted segments.

Conclusions: The computerized analysis of the remodelling process shows that  regression of the remodelling process is clearly supe- rior in patients with primary PCI in both infarcted and  noninfarcted segments. Also, it proves the  role of C3DE in showing the  possible role of stem cell therapy in recovery of LV function after  AMI.

Tags: Coronary revascularisation, Stem cell transplant, Ventricular remodelling